Academic Qualification:

1. Ph.D. in Tumor Immunobiology, Biotechnology University of Calcutta.
2. Masters in Science in Zoology, University of Calcutta.
3. Bachelors in Science (Honours), Lady Brabourne College, University of Calcutta.

Academic positions:

1. Scientist B: 2022 onwards, DBT-Institute of Life Sciences, Bhubaneswar, Odisha, India
2. Postdoctoral Fellow: 2021- 2022, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
3. Research Associate III: 2019-2020, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
4. Senior Research Fellow (UGC): 2016-2019, Department of Zoology, University of Calcutta, Kolkata
5. Junior Research Fellow (UGC): 2014-2016, Department of Zoology, University of Calcutta, Kolkata
6. Junior Research Fellow (DST): 2013-2014, Department of Zoology, University of Calcutta, Kolkata.

Memberships:

• Life member, The Zoological Society, Kolkata
• The American Association of Immunologists (2022-2023)
• Indian Immunology Society (2015-2017)
• Indian Association for Cancer Research (2014-2015)

RESEARCH

Traditionally, tumor immunology has been chiefly centered on T lymphocytes, but T cells do not work alone. A coordinated humoral response with cellular arm of adaptive immunity develops robust and sustained effectiveness and long-term memory. Although, B lymphocytes have been correlated with cancer-promoting activities, recent evidence exhibit that humoral response is associated with immune protection in multiple cancers. The cross-talk of B lymphocytes with other immune cells at tumor beds, apart from T cells, is an area that needs to be thoroughly investigated. Germinal center formation in epithelial malignancies is a complex process that ensures production of protective anti-tumor antibodies at tumor beds, and we speculate that orchestration of tertiary-lymphoid-structures that eventually leads to germinal centers is largely dependent on non-B, non-T immune and non-immune cells. Utilizing the enduring knowledge in the field of cancer biology and tumor immunology, the long-term goal of the Mandal laboratory at DBT-Institute of Life Sciences is to build a comprehensive understanding of how the cells in the tumor microenvironment direct the nature of spontaneous immune pressure at different solid cancers within the tumor microenvironment, with a special focus on cancers that specifically affects women. The immediate aim of our lab is to holistically examine the impact of crosstalk between cancer cells and tumor-infiltrating lymphocytes and other immune cells in driving or dampening a sustained, robust anti-tumor immune response.

SELECTED PUBLICATIONS

.

Click here for complete list of publications